In the quest for better sleep, it’s tempting to reach for the familiar: a melatonin supplement, marketed as the natural “sleep hormone.”
But recent research shows that relying on melatonin night after night may carry surprising risks, and that’s where a high‑quality melatonin‑free option can be worth considering.
The Heart Health Concerns with Long-Term Melatonin Use
A groundbreaking multinational study presented at the American Heart Association’s 2025 Scientific Sessions analyzed over 130,000 adults with insomnia who used melatonin for at least one year.
The findings were alarming:
- Long-term melatonin users faced a 90% higher risk of heart failure over five years compared to non-users.
- The study also revealed that melatonin users were nearly 3.5 times more likely to be hospitalized for heart failure and twice as likely to die from any cause during the same period.
While the study demonstrates a strong association rather than a direct cause-and-effect relationship, the results are significant enough to prompt caution. Researchers emphasize that more studies, particularly randomized controlled trials, are needed to confirm these findings and understand the underlying biological mechanisms.
Still, the consistency and magnitude of the increased risks are noteworthy, especially given melatonin’s widespread reputation as a “safe” and “natural” sleep aid.
Why This Matters, Beyond the Headlines
Sleep & Heart Health Are Deeply Connected
Quality sleep isn’t just about feeling rested; it’s a foundational pillar of health. Poor or fragmented sleep has been linked to elevated blood pressure, impaired glucose metabolism, greater inflammation, and increased cardiovascular risk.
Thus, when a study links sleep aids (or their long‑term use) with cardiovascular outcomes, it raises critical questions: Is the risk from the underlying sleep disorder? The supplement? The dosing or formulation (especially with unregulated OTC melatonin)?
Melatonin’s Traditional Role & Emerging Concerns
- Melatonin is a hormone produced by the pineal gland, triggered by darkness, and helps regulate the sleep‑wake (circadian) rhythm.
- As a supplement, it’s widely used for short‑term issues like jet lag or shift‑work sleep disruption.
- But for chronic insomnia or nightly use over many months, the evidence of safety and long‑term benefit is far weaker. The new study shines a spotlight on one serious potential risk: heart failure, hospitalizations, and possibly mortality.
By contrast, treatment of sleep issues ideally addresses root causes (poor sleep hygiene, untreated sleep apnea, anxiety/stress, circadian rhythm disruption) rather than long‑term reliance on a hormone. Many sleep specialists argue that you'd want to engage behavioral strategies first.
Why Choose Melatonin-Free Sleep Solutions?
Given these concerns, many people are turning to melatonin-free sleep aids, such as lost range.® CBD’s sleep gummies. These products harness the power of plant-based cannabinoids to help promote deep relaxation and restful sleep without relying on hormones or synthetic substances.
The Power of CBD and CBN
lost range.® CBD’s melatonin-free sleep gummies feature a potent blend of full-spectrum CBD and CBN (cannabinol), two naturally occurring cannabinoids found in hemp. Each gummy delivers 33mg of full-spectrum CBD and 10mg of CBN, a ratio specifically formulated to balance the calming properties of CBD with the sleep-enhancing power of CBN.
- CBD (Cannabidiol): Known for its calming effects, CBD interacts with the body’s endocannabinoid system, which plays a crucial role in regulating mood, stress, and sleep. By reducing anxiety and promoting relaxation, CBD helps create the ideal conditions for falling asleep naturally.
- CBN (Cannabinol): CBN is gaining recognition for its ability to promote sleep and relaxation. When combined with CBD, CBN enhances the overall sleep-supporting effects, making these gummies particularly effective for individuals with moderate to severe sleep challenges.
How CBD and CBN Can Help Support Sleep
Unlike melatonin, which directly influences the sleep-wake cycle by mimicking the body’s natural hormone, CBD and CBN work indirectly by addressing the underlying causes of poor sleep, such as stress, anxiety, and physical discomfort. This approach helps the body and mind settle into a calm state, making it easier to fall asleep and stay asleep throughout the night.
- Reducing Sleep Latency: CBD and CBN can help shorten the time it takes to fall asleep, making it easier to drift off after a long day.
- Improving Sleep Continuity: These cannabinoids support uninterrupted sleep, reducing the number of times you wake up during the night.
- Enhancing Sleep Depth: By promoting deeper, more restorative sleep, CBD and CBN help ensure you wake up feeling refreshed and rejuvenated.
- Reducing Anxiety: Both CBD and CBN have calming effects that can help quiet a racing mind, making it easier to relax at bedtime.
The Benefits of Melatonin-Free Sleep Gummies
Choosing melatonin-free sleep gummies offers several advantages over traditional melatonin-based products:
- No Hormonal Interference: Melatonin-free gummies do not interfere with the body’s natural hormone production, reducing the risk of side effects and dependency.
- Non-Habit-Forming: Unlike some traditional sleep aids, CBD and CBN are non-habit-forming, allowing you to use them regularly without worrying about developing a dependency.
- No Next-Day Drowsiness: Many people report feeling groggy or drowsy the morning after taking melatonin. Melatonin-free sleep gummies aim to provide restful sleep without the hangover effect, helping you wake up refreshed and ready to tackle the day.
- Natural Ingredients: Crafted with high-quality, plant-based components, these gummies prioritize natural wellness and gentle effects, making them a preferred choice for individuals seeking a holistic approach to better sleep.
How to Use Them for the Best Effect
To get the most from melatonin‑free sleep support, combine a high‑quality product + strong sleep hygiene + lifestyle support. Here’s a recommended routine:
Step 1: Wind‑down routine (~60 minutes before bed)
- Dim lights, reduce screen/blue‑light exposure.
- Avoid caffeine and heavy meals at least 2–3 hours before bed.
- Engage in calming activity: reading, stretching, gentle yoga, meditation, or deep breathing.
- Set your bedroom environment: cool (~65 °F/18 °C), dark, quiet, comfortable.
Step 2: Take your gummy (~30‑45 minutes before lights‑out)
- If you’re new: start with ½ a gummy (≈ 16 mg CBD + 5 mg CBN) and see how your body responds.
- On the following nights, you may move to 1 full gummy (33 mg CBD + 10 mg CBN) if needed.
- Try to take it at the same time each night to support a consistent routine.
Step 3: Maintain consistent habits
- Go to bed and wake up at the same time each day (yes, even weekends).
- Avoid heavy screens or stimulating activity right before bed.
- If you wake during the night, resist the urge to check phones/bright screens; instead, use a dim light and calm activity.
Step 4: Evaluate results (30‑45 days)
- Monitor how you feel in the morning: Did you wake refreshed or groggy?
- Track the number of awakenings or how long it takes you to fall asleep.
- If after ~4–6 weeks you’re not seeing improvement, consider consulting a sleep specialist (to rule out issues like sleep apnea, restless legs, circadian rhythm disorders).
Final Thoughts
Sleep is foundational. It’s about more than “falling asleep fast”; it’s about deep, restorative rest, regular cycles, waking refreshed and ready. The choices we make around sleep aids matter, especially when we rely on them night after night.
While melatonin may still serve a role (short‑term, situational), the emerging data around its long‑term use raise caution flags. If you’re seeking reliable nightly support without introducing a hormone into your system, the melatonin‑free approach offered by lost range.® CBD+CBN Sleep Gummies offers a thoughtful alternative: plant‑based, non‑hormonal, crafted with quality, and aligned with ongoing sleep‑health practices.
Here’s to brighter mornings, deeper nights, and smarter sleep, every night.
Shop our melatonin-free sleep gummies at lostrangecbd.com.
Important Disclaimer
This blog is educational only; not medical advice. Always consult your healthcare provider before using any new supplement, especially if you have underlying health conditions (e.g., heart disease, insomnia, sleep apnea), are pregnant/nursing, or are taking other medications
